About Ubiquitin-conjugating enzyme E2 E1
Ubiquitin-conjugating enzyme E2 E1 (UBE2E1) is a protein
from Homo sapiens identified by UniProt accession
P51965, 193 residues long.
MolForge cross-references it against 0 known binders and
121 disease associations.
Target properties
| Protein name | Ubiquitin-conjugating enzyme E2 E1 |
|---|
| UniProt accession | P51965 |
|---|
| Gene | UBE2E1 |
|---|
| Organism | Homo sapiens |
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| Length | 193 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (121)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.25
- endometrial cancer · score 0.21
- FEV/FVC ratio · score 0.17
- response to bronchodilator · score 0.17
- blood protein measurement · score 0.16
- esophageal cancer · score 0.13
- substance abuse · score 0.13
- attention deficit hyperactivity disorder · score 0.13
- antisocial behaviour measurement · score 0.13
- smoking status measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51965-F1 | alphafold | PREDICTED | 86.66 | — |
Amino-acid sequence (193 residues)
MSDDDSRAST SSSSSSSSNQ QTEKETNTPK KKESKVSMSK NSKLLSTSAK RIQKELADIT LDPPPNCSAG PKGDNIYEWR STILGPPGSV YEGGVFFLDI TFTPEYPFKP PKVTFRTRIY HCNINSQGVI CLDILKDNWS PALTISKVLL SICSLLTDCN PADPLVGSIA TQYMTNRAEH DRMARQWTKR YAT
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