About NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (NDUFA8) is a protein
from Homo sapiens identified by UniProt accession
P51970, 172 residues long.
MolForge cross-references it against 0 known binders and
313 disease associations.
Target properties
| Protein name | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 |
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| UniProt accession | P51970 |
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| Gene | NDUFA8 |
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| Organism | Homo sapiens |
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| Length | 172 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (313)
Diseases linked to this target (Open Targets).
- mitochondrial complex 1 deficiency, nuclear type 37 · score 0.71
- type 2 diabetes mellitus · score 0.61
- diabetes mellitus · score 0.60
- polycystic ovary syndrome · score 0.60
- type 1 diabetes mellitus · score 0.58
- gestational diabetes · score 0.58
- neurodegenerative disease · score 0.58
- obesity · score 0.57
- prediabetes syndrome · score 0.56
- schizophrenia · score 0.55
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P51970-F1 | alphafold | PREDICTED | 93.92 | — |
Amino-acid sequence (172 residues)
MPGIVELPTL EELKVDEVKI SSAVLKAAAH HYGAQCDKPN KEFMLCRWEE KDPRRCLEEG KLVNKCALDF FRQIKRHCAE PFTEYWTCID YTGQQLFRHC RKQQAKFDEC VLDKLGWVRP DLGELSKVTK VKTDRPLPEN PYHSRPRPDP SPEIEGDLQP ATHGSRFYFW TK
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