About Rho-related GTP-binding protein RhoN
Rho-related GTP-binding protein RhoN (RND2) is a protein
from Homo sapiens identified by UniProt accession
P52198, 227 residues long.
MolForge cross-references it against 0 known binders and
92 disease associations.
Target properties
| Protein name | Rho-related GTP-binding protein RhoN |
|---|
| UniProt accession | P52198 |
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| Gene | RND2 |
|---|
| Organism | Homo sapiens |
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| Length | 227 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (92)
Diseases linked to this target (Open Targets).
- age at menopause · score 0.12
- neutrophil count · score 0.08
- leukocyte count · score 0.08
- glioblastoma multiforme · score 0.08
- myeloid white cell count · score 0.07
- aspartate aminotransferase measurement · score 0.07
- hypertrophic cardiomyopathy · score 0.07
- glioblastoma · score 0.06
- Arrhythmogenic right ventricular dysplasia · score 0.06
- menopause · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P52198-F1 | alphafold | PREDICTED | 83.69 | — |
Amino-acid sequence (227 residues)
MEGQSGRCKI VVVGDAECGK TALLQVFAKD AYPGSYVPTV FENYTASFEI DKRRIELNMW DTSGSSYYDN VRPLAYPDSD AVLICFDISR PETLDSVLKK WQGETQEFCP NAKVVLVGCK LDMRTDLATL RELSKQRLIP VTHEQGTVLA KQVGAVSYVE CSSRSSERSV RDVFHVATVA SLGRGHRQLR RTDSRRGMQR SAQLSGRPDR GNEGEIHKDR AKSCNLM
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