About 6-phosphogluconate dehydrogenase, decarboxylating
6-phosphogluconate dehydrogenase, decarboxylating (PGD) is a protein
from Homo sapiens identified by UniProt accession
P52209, 483 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | 6-phosphogluconate dehydrogenase, decarboxylating |
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| UniProt accession | P52209 |
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| Gene | PGD |
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| Organism | Homo sapiens |
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| Length | 483 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (86)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.42
- neuroinflammatory disorder · score 0.25
- platelet count · score 0.20
- BMI-adjusted waist circumference · score 0.20
- mean platelet volume · score 0.20
- grip strength measurement · score 0.19
- body fat distribution · score 0.19
- hemoglobin measurement · score 0.17
- hematocrit · score 0.17
- erythrocyte count · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P52209-F1 | alphafold | PREDICTED | 96.81 | — |
Amino-acid sequence (483 residues)
MAQADIALIG LAVMGQNLIL NMNDHGFVVC AFNRTVSKVD DFLANEAKGT KVVGAQSLKE MVSKLKKPRR IILLVKAGQA VDDFIEKLVP LLDTGDIIID GGNSEYRDTT RRCRDLKAKG ILFVGSGVSG GEEGARYGPS LMPGGNKEAW PHIKTIFQGI AAKVGTGEPC CDWVGDEGAG HFVKMVHNGI EYGDMQLICE AYHLMKDVLG MAQDEMAQAF EDWNKTELDS FLIEITANIL KFQDTDGKHL LPKIRDSAGQ KGTGKWTAIS ALEYGVPVTL IGEAVFARCL SSLKDERIQA SKKLKGPQKF QFDGDKKSFL EDIRKALYAS KIISYAQGFM LLRQAATEFG WTLNYGGIAL MWRGGCIIRS VFLGKIKDAF DRNPELQNLL LDDFFKSAVE NCQDSWRRAV STGVQAGIPM PCFTTALSFY DGYRHEMLPA SLIQAQRDYF GAHTYELLAK PGQFIHTNWT GHGGTVSSSS YNA
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