About Heterogeneous nuclear ribonucleoprotein M
Heterogeneous nuclear ribonucleoprotein M (HNRNPM) is a protein
from Homo sapiens identified by UniProt accession
P52272, 730 residues long.
MolForge cross-references it against 0 known binders and
171 disease associations.
Target properties
| Protein name | Heterogeneous nuclear ribonucleoprotein M |
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| UniProt accession | P52272 |
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| Gene | HNRNPM |
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| Organism | Homo sapiens |
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| Length | 730 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (171)
Diseases linked to this target (Open Targets).
- lung adenocarcinoma · score 0.23
- appendicular lean mass · score 0.22
- Red cell distribution width · score 0.20
- heel bone mineral density · score 0.19
- cutaneous melanoma · score 0.18
- mean corpuscular volume · score 0.16
- fat body mass · score 0.14
- head and neck squamous cell carcinoma · score 0.11
- mean corpuscular hemoglobin · score 0.11
- hepatocellular carcinoma · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P52272-F1 | alphafold | PREDICTED | 54.79 | — |
Amino-acid sequence (730 residues)
MAAGVEAAAE VAATEIKMEE ESGAPGVPSG NGAPGPKGEG ERPAQNEKRK EKNIKRGGNR FEPYANPTKR YRAFITNIPF DVKWQSLKDL VKEKVGEVTY VELLMDAEGK SRGCAVVEFK MEESMKKAAE VLNKHSLSGR PLKVKEDPDG EHARRAMQKV MATTGGMGMG PGGPGMITIP PSILNNPNIP NEIIHALQAG RLGSTVFVAN LDYKVGWKKL KEVFSMAGVV VRADILEDKD GKSRGIGTVT FEQSIEAVQA ISMFNGQLLF DRPMHVKMDE RALPKGDFFP PERPQQLPHG LGGIGMGLGP GGQPIDANHL NKGIGMGNIG PAGMGMEGIG FGINKMGGME GPFGGGMENM GRFGSGMNMG RINEILSNAL KRGEIIAKQG GGGGGGSVPG IERMGPGIDR LGGAGMERMG AGLGHGMDRV GSEIERMGLV MDRMGSVERM GSGIERMGPL GLDHMASSIE RMGQTMERIG SGVERMGAGM GFGLERMAAP IDRVGQTIER MGSGVERMGP AIERMGLSME RMVPAGMGAG LERMGPVMDR MATGLERMGA NNLERMGLER MGANSLERMG LERMGANSLE RMGPAMGPAL GAGIERMGLA MGGGGGASFD RAIEMERGNF GGSFAGSFGG AGGHAPGVAR KACQIFVRNL PFDFTWKMLK DKFNECGHVL YADIKMENGK SKGCGVVKFE SPEVAERACR MMNGMKLSGR EIDVRIDRNA
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