Importin subunit alpha-1 (KPNA2)

About Importin subunit alpha-1

Importin subunit alpha-1 (KPNA2) is a protein from Homo sapiens identified by UniProt accession P52292, 529 residues long. MolForge cross-references it against 0 known binders and 282 disease associations.

Target properties

Protein name	Importin subunit alpha-1
UniProt accession	P52292
Gene	KPNA2
Organism	Homo sapiens
Length	529 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (282)

Diseases linked to this target (Open Targets).

influenza · score 0.46
severe acute respiratory syndrome · score 0.46
COVID-19 · score 0.37
FEV/FVC ratio · score 0.35
eosinophil count · score 0.35
peripheral arterial disease · score 0.33
loneliness measurement · score 0.32
eosinophil percentage of leukocytes · score 0.30
lymphocyte count · score 0.29
heel bone mineral density · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P52292-F1	alphafold	PREDICTED	86.52	—

Amino-acid sequence (529 residues)

MSTNENANTP AARLHRFKNK GKDSTEMRRR RIEVNVELRK AKKDDQMLKR RNVSSFPDDA TSPLQENRNN QGTVNWSVDD IVKGINSSNV ENQLQATQAA RKLLSREKQP PIDNIIRAGL IPKFVSFLGR TDCSPIQFES AWALTNIASG TSEQTKAVVD GGAIPAFISL LASPHAHISE QAVWALGNIA GDGSVFRDLV IKYGAVDPLL ALLAVPDMSS LACGYLRNLT WTLSNLCRNK NPAPPIDAVE QILPTLVRLL HHDDPEVLAD TCWAISYLTD GPNERIGMVV KTGVVPQLVK LLGASELPIV TPALRAIGNI VTGTDEQTQV VIDAGALAVF PSLLTNPKTN IQKEATWTMS NITAGRQDQI QQVVNHGLVP FLVSVLSKAD FKTQKEAVWA VTNYTSGGTV EQIVYLVHCG IIEPLMNLLT AKDTKIILVI LDAISNIFQA AEKLGETEKL SIMIEECGGL DKIEALQNHE NESVYKASLS LIEKYFSVEE EEDQNVVPET TSEGYTFQVQ DGAPGTFNF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards