Nuclear cap-binding protein subunit 2 (NCBP2)

About Nuclear cap-binding protein subunit 2

Nuclear cap-binding protein subunit 2 (NCBP2) is a protein from Homo sapiens identified by UniProt accession P52298, 156 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.

Target properties

Protein name	Nuclear cap-binding protein subunit 2
UniProt accession	P52298
Gene	NCBP2
Organism	Homo sapiens
Length	156 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (47)

Diseases linked to this target (Open Targets).

HIV infection · score 0.59
neurodegenerative disease · score 0.54
acrocephalosyndactyly · score 0.37
ulcerative colitis · score 0.36
endometrial cancer · score 0.28
lung adenocarcinoma · score 0.27
breast adenocarcinoma · score 0.26
glioblastoma multiforme · score 0.26
head and neck squamous cell carcinoma · score 0.23
viral load · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P52298-F1	alphafold	PREDICTED	93.44	—

Amino-acid sequence (156 residues)

MSGGLLKALR SDSYVELSQY RDQHFRGDNE EQEKLLKKSC TLYVGNLSFY TTEEQIYELF SKSGDIKKII MGLDKMKKTA CGFCFVEYYS RADAENAMRY INGTRLDDRI IRTDWDAGFK EGRQYGRGRS GGQVRDEYRQ DYDAGRGGYG KLAQNQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards