About Diacylglycerol kinase epsilon
Diacylglycerol kinase epsilon (DGKE) is a protein
from Homo sapiens identified by UniProt accession
P52429, 567 residues long.
MolForge cross-references it against 0 known binders and
132 disease associations.
Target properties
| Protein name | Diacylglycerol kinase epsilon |
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| UniProt accession | P52429 |
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| Gene | DGKE |
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| Organism | Homo sapiens |
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| Length | 567 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (132)
Diseases linked to this target (Open Targets).
- immunoglobulin-mediated membranoproliferative glomerulonephritis · score 0.78
- nephrotic syndrome · score 0.69
- atypical hemolytic-uremic syndrome · score 0.62
- neurodegenerative disease · score 0.52
- atypical hemolytic-uremic syndrome with DGKE deficiency · score 0.37
- non-immunoglobulin-mediated membranoproliferative glomerulonephritis · score 0.37
- hemolytic-uremic syndrome · score 0.34
- total blood protein measurement · score 0.27
- breast adenocarcinoma · score 0.25
- blood protein measurement · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P52429-F1 | alphafold | PREDICTED | 86.03 | — |
Amino-acid sequence (567 residues)
MEAERRPAPG SPSEGLFADG HLILWTLCSV LLPVFITFWC SLQRSRRQLH RRDIFRKSKH GWRDTDLFSQ PTYCCVCAQH ILQGAFCDCC GLRVDEGCLR KADKRFQCKE IMLKNDTKVL DAMPHHWIRG NVPLCSYCMV CKQQCGCQPK LCDYRCIWCQ KTVHDECMKN SLKNEKCDFG EFKNLIIPPS YLTSINQMRK DKKTDYEVLA SKLGKQWTPL IILANSRSGT NMGEGLLGEF RILLNPVQVF DVTKTPPIKA LQLCTLLPYY SARVLVCGGD GTVGWVLDAV DDMKIKGQEK YIPQVAVLPL GTGNDLSNTL GWGTGYAGEI PVAQVLRNVM EADGIKLDRW KVQVTNKGYY NLRKPKEFTM NNYFSVGPDA LMALNFHAHR EKAPSLFSSR ILNKAVYLFY GTKDCLVQEC KDLNKKVELE LDGERVALPS LEGIIVLNIG YWGGGCRLWE GMGDETYPLA RHDDGLLEVV GVYGSFHCAQ IQVKLANPFR IGQAHTVRLI LKCSMMPMQV DGEPWAQGPC TVTITHKTHA MMLYFSGEQT DDDISSTSDQ EDIKATE
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