DNA-directed RNA polymerases I, II, and III subunit…

About DNA-directed RNA polymerases I, II, and III subunit RPABC3

DNA-directed RNA polymerases I, II, and III subunit RPABC3 (POLR2H) is a protein from Homo sapiens identified by UniProt accession P52434, 150 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	DNA-directed RNA polymerases I, II, and III subunit RPABC3
UniProt accession	P52434
Gene	POLR2H
Organism	Homo sapiens
Length	150 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (52)

Diseases linked to this target (Open Targets).

HIV infection · score 0.60
acrocephalosyndactyly · score 0.37
influenza · score 0.37
endometrial cancer · score 0.29
breast adenocarcinoma · score 0.28
lung adenocarcinoma · score 0.27
head and neck squamous cell carcinoma · score 0.26
cutaneous melanoma · score 0.24
platelet count · score 0.23
platelet crit · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P52434-F1	alphafold	PREDICTED	84.24	—

Amino-acid sequence (150 residues)

MAGILFEDIF DVKDIDPEGK KFDRVSRLHC ESESFKMDLI LDVNIQIYPV DLGDKFRLVI ASTLYEDGTL DDGEYNPTDD RPSRADQFEY VMYGKVYRIE GDETSTEAAT RLSAYVSYGG LLMRLQGDAN NLHGFEVDSR VYLLMKKLAF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

DNA-directed RNA polymerases I, II, and III subunit RPABC3 (POLR2H)