DNA-directed RNA polymerase II subunit RPB11-a…

About DNA-directed RNA polymerase II subunit RPB11-a

DNA-directed RNA polymerase II subunit RPB11-a (POLR2J) is a protein from Homo sapiens identified by UniProt accession P52435, 117 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.

Target properties

Protein name	DNA-directed RNA polymerase II subunit RPB11-a
UniProt accession	P52435
Gene	POLR2J
Organism	Homo sapiens
Length	117 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (27)

Diseases linked to this target (Open Targets).

HIV infection · score 0.60
acrocephalosyndactyly · score 0.37
influenza · score 0.37
mean platelet volume · score 0.32
breast adenocarcinoma · score 0.28
endometrial cancer · score 0.28
chronotype measurement · score 0.25
cutaneous melanoma · score 0.24
glioblastoma multiforme · score 0.04
appendicular lean mass · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P52435-F1	alphafold	PREDICTED	94.22	—

Amino-acid sequence (117 residues)

MNAPPAFESF LLFEGEKKIT INKDTKVPNA CLFTINKEDH TLGNIIKSQL LKDPQVLFAG YKVPHPLEHK IIIRVQTTPD YSPQEAFTNA ITDLISELSL LEERFRVAIK DKQEGIE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

DNA-directed RNA polymerase II subunit RPB11-a (POLR2J)