About Dual specificity mitogen-activated protein kinase kinase 6
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6) is a protein
from Homo sapiens identified by UniProt accession
P52564, 334 residues long.
MolForge cross-references it against 0 known binders and
156 disease associations.
Target properties
| Protein name | Dual specificity mitogen-activated protein kinase kinase 6 |
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| UniProt accession | P52564 |
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| Gene | MAP2K6 |
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| Organism | Homo sapiens |
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| Length | 334 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (8)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (156)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- lean body mass · score 0.47
- osteoarthritis, hip · score 0.46
- appendicular lean mass · score 0.46
- body height · score 0.45
- osteoarthritis, knee · score 0.40
- BMI-adjusted waist circumference · score 0.39
- anthrax infection · score 0.37
- neuroinflammatory disorder · score 0.37
- BMI-adjusted waist-hip ratio · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P52564-F1 | alphafold | PREDICTED | 79.20 | — |
Amino-acid sequence (334 residues)
MSQSKGKKRN PGLKIPKEAF EQPQTSSTPP RDLDSKACIS IGNQNFEVKA DDLEPIMELG RGAYGVVEKM RHVPSGQIMA VKRIRATVNS QEQKRLLMDL DISMRTVDCP FTVTFYGALF REGDVWICME LMDTSLDKFY KQVIDKGQTI PEDILGKIAV SIVKALEHLH SKLSVIHRDV KPSNVLINAL GQVKMCDFGI SGYLVDSVAK TIDAGCKPYM APERINPELN QKGYSVKSDI WSLGITMIEL AILRFPYDSW GTPFQQLKQV VEEPSPQLPA DKFSAEFVDF TSQCLKKNSK ERPTYPELMQ HPFFTLHESK GTDVASFVKL ILGD
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