About Rho GDP-dissociation inhibitor 1
Rho GDP-dissociation inhibitor 1 (ARHGDIA) is a protein
from Homo sapiens identified by UniProt accession
P52565, 204 residues long.
MolForge cross-references it against 0 known binders and
145 disease associations.
Target properties
| Protein name | Rho GDP-dissociation inhibitor 1 |
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| UniProt accession | P52565 |
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| Gene | ARHGDIA |
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| Organism | Homo sapiens |
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| Length | 204 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (145)
Diseases linked to this target (Open Targets).
- nephrotic syndrome · score 0.65
- neurodegenerative disease · score 0.50
- familial idiopathic steroid-resistant nephrotic syndrome · score 0.38
- genetic disorder · score 0.19
- congenital nephrotic syndrome, Finnish type · score 0.13
- chronic kidney disease · score 0.12
- gastric adenocarcinoma · score 0.10
- cancer · score 0.07
- hepatocellular carcinoma · score 0.04
- hematocrit · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P52565-F1 | alphafold | PREDICTED | 90.34 | — |
Amino-acid sequence (204 residues)
MAEQEPTAEQ LAQIAAENEE DEHSVNYKPP AQKSIQEIQE LDKDDESLRK YKEALLGRVA VSADPNVPNV VVTGLTLVCS SAPGPLELDL TGDLESFKKQ SFVLKEGVEY RIKISFRVNR EIVSGMKYIQ HTYRKGVKID KTDYMVGSYG PRAEEYEFLT PVEEAPKGML ARGSYSIKSR FTDDDKTDHL SWEWNLTIKK DWKD
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