About Rho GDP-dissociation inhibitor 2
Rho GDP-dissociation inhibitor 2 (ARHGDIB) is a protein
from Homo sapiens identified by UniProt accession
P52566, 201 residues long.
MolForge cross-references it against 0 known binders and
146 disease associations.
Target properties
| Protein name | Rho GDP-dissociation inhibitor 2 |
|---|
| UniProt accession | P52566 |
|---|
| Gene | ARHGDIB |
|---|
| Organism | Homo sapiens |
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| Length | 201 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (146)
Diseases linked to this target (Open Targets).
- inflammatory bowel disease · score 0.16
- platelet component distribution width · score 0.13
- 1,5 anhydroglucitol measurement · score 0.11
- urate measurement · score 0.11
- breast cancer · score 0.08
- acute lymphoblastic leukemia · score 0.07
- hemoglobin measurement · score 0.07
- FEV/FVC ratio · score 0.06
- hematocrit · score 0.06
- red blood cell density measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P52566-F1 | alphafold | PREDICTED | 87.73 | — |
Amino-acid sequence (201 residues)
MTEKAPEPHV EEDDDDELDS KLNYKPPPQK SLKELQEMDK DDESLIKYKK TLLGDGPVVT DPKAPNVVVT RLTLVCESAP GPITMDLTGD LEALKKETIV LKEGSEYRVK IHFKVNRDIV SGLKYVQHTY RTGVKVDKAT FMVGSYGPRP EEYEFLTPVE EAPKGMLARG TYHNKSFFTD DDKQDHLSWE WNLSIKKEWT E
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