About Arf-GAP domain and FG repeat-containing protein 1
Arf-GAP domain and FG repeat-containing protein 1 (AGFG1) is a protein
from Homo sapiens identified by UniProt accession
P52594, 562 residues long.
MolForge cross-references it against 0 known binders and
347 disease associations.
Target properties
| Protein name | Arf-GAP domain and FG repeat-containing protein 1 |
|---|
| UniProt accession | P52594 |
|---|
| Gene | AGFG1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 562 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (347)
Diseases linked to this target (Open Targets).
- cortical surface area measurement · score 0.31
- cortical thickness · score 0.30
- body height · score 0.30
- eosinophil count · score 0.27
- influenza A (H1N1) · score 0.25
- leukocyte count · score 0.24
- brain measurement · score 0.24
- myeloid white cell count · score 0.23
- glioblastoma multiforme · score 0.23
- monocyte count · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P52594-F1 | alphafold | PREDICTED | 56.13 | — |
Amino-acid sequence (562 residues)
MAASAKRKQE EKHLKMLRDM TGLPHNRKCF DCDQRGPTYV NMTVGSFVCT SCSGSLRGLN PPHRVKSISM TTFTQQEIEF LQKHGNEVCK QIWLGLFDDR SSAIPDFRDP QKVKEFLQEK YEKKRWYVPP EQAKVVASVH ASISGSSASS TSSTPEVKPL KSLLGDSAPT LHLNKGTPSQ SPVVGRSQGQ QQEKKQFDLL SDLGSDIFAA PAPQSTATAN FANFAHFNSH AAQNSANADF ANFDAFGQSS GSSNFGGFPT ASHSPFQPQT TGGSAASVNA NFAHFDNFPK SSSADFGTFN TSQSHQTASA VSKVSTNKAG LQTADKYAAL ANLDNIFSAG QGGDQGSGFG TTGKAPVGSV VSVPSQSSAS SDKYAALAEL DSVFSSAATS SNAYTSTSNA SSNVFGTVPV VASAQTQPAS SSVPAPFGAT PSTNPFVAAA GPSVASSTNP FQTNARGATA ATFGTASMSM PTGFGTPAPY SLPTSFSGSF QQPAFPAQAA FPQQTAFSQQ PNGAGFAAFG QTKPVVTPFG QVAAAGVSSN PFMTGAPTGQ FPTGSSSTNP FL
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