Transcription initiation factor IIA subunit 1 (GTF2A1)

About Transcription initiation factor IIA subunit 1

Transcription initiation factor IIA subunit 1 (GTF2A1) is a protein from Homo sapiens identified by UniProt accession P52655, 376 residues long. MolForge cross-references it against 0 known binders and 123 disease associations.

Target properties

Protein name	Transcription initiation factor IIA subunit 1
UniProt accession	P52655
Gene	GTF2A1
Organism	Homo sapiens
Length	376 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (123)

Diseases linked to this target (Open Targets).

HIV infection · score 0.58
neutrophil count · score 0.48
leukocyte count · score 0.46
high density lipoprotein cholesterol measurement · score 0.46
mean corpuscular hemoglobin · score 0.45
mean corpuscular hemoglobin concentration · score 0.44
neurodegenerative disease · score 0.43
erythrocyte count · score 0.43
apolipoprotein A 1 measurement · score 0.40
myeloid white cell count · score 0.40

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P52655-F1	alphafold	PREDICTED	55.62	—

Amino-acid sequence (376 residues)

MANSANTNTV PKLYRSVIED VINDVRDIFL DDGVDEQVLM ELKTLWENKL MQSRAVDGFH SEEQQLLLQV QQQHQPQQQQ HHHHHHHQQA QPQQTVPQQA QTQQVLIPAS QQATAPQVIV PDSKLIQHMN ASNMSAAATA ATLALPAGVT PVQQILTNSG QLLQVVRAAN GAQYIFQPQQ SVVLQQQVIP QMQPGGVQAP VIQQVLAPLP GGISPQTGVI IQPQQILFTG NKTQVIPTTV AAPTPAQAQI TATGQQQPQA QPAQTQAPLV LQVDGTGDTS SEEDEDEEED YDDDEEEDKE KDGAEDGQVE EEPLNSEDDV SDEEGQELFD TENVVVCQYD KIHRSKNKWK FHLKDGIMNL NGRDYIFSKA IGDAEW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards