About Transcription initiation factor IIA subunit 2
Transcription initiation factor IIA subunit 2 (GTF2A2) is a protein
from Homo sapiens identified by UniProt accession
P52657, 109 residues long.
MolForge cross-references it against 0 known binders and
24 disease associations.
Target properties
| Protein name | Transcription initiation factor IIA subunit 2 |
|---|
| UniProt accession | P52657 |
|---|
| Gene | GTF2A2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 109 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (24)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.58
- neurodegenerative disease · score 0.49
- sex hormone-binding globulin measurement · score 0.21
- macula measurement · score 0.14
- lymphocyte percentage of leukocytes · score 0.11
- high density lipoprotein cholesterol measurement · score 0.11
- neutrophil percentage of leukocytes · score 0.11
- gut microbiome measurement · score 0.07
- taxonomic microbiome measurement · score 0.07
- mean platelet volume · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P52657-F1 | alphafold | PREDICTED | 93.06 | — |
Amino-acid sequence (109 residues)
MAYQLYRNTT LGNSLQESLD ELIQSQQITP QLALQVLLQF DKAINAALAQ RVRNRVNFRG SLNTYRFCDN VWTFVLNDVE FREVTELIKV DKVKIVACDG KNTGSNTTE
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