About Guanine nucleotide exchange factor VAV2
Guanine nucleotide exchange factor VAV2 (VAV2) is a protein
from Homo sapiens identified by UniProt accession
P52735, 878 residues long.
MolForge cross-references it against 0 known binders and
243 disease associations.
Target properties
| Protein name | Guanine nucleotide exchange factor VAV2 |
|---|
| UniProt accession | P52735 |
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| Gene | VAV2 |
|---|
| Organism | Homo sapiens |
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| Length | 878 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (243)
Diseases linked to this target (Open Targets).
- cutaneous Leishmaniasis · score 0.50
- hematocrit · score 0.45
- hemoglobin measurement · score 0.45
- erythrocyte count · score 0.39
- red blood cell density measurement · score 0.34
- viral load · score 0.31
- thyroid gland adenocarcinoma · score 0.28
- breast adenocarcinoma · score 0.28
- glioblastoma multiforme · score 0.27
- endometrial cancer · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P52735-F1 | alphafold | PREDICTED | 83.15 | — |
Amino-acid sequence (878 residues)
MEQWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL SPGSIDLKDI NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SELFDPFDLF DVRDFGKVIS AVSRLSLHSI AQNKGIRPFP SEETTENDDD VYRSLEELAD EHDLGEDIYD CVPCEDGGDD IYEDIIKVEV QQPMIRYMQK MGMTEDDKRN CCLLEIQETE AKYYRTLEDI EKNYMSPLRL VLSPADMAAV FINLEDLIKV HHSFLRAIDV SVMVGGSTLA KVFLDFKERL LIYGEYCSHM EHAQNTLNQL LASREDFRQK VEECTLKVQD GKFKLQDLLV VPMQRVLKYH LLLKELLSHS AERPERQQLK EALEAMQDLA MYINEVKRDK ETLRKISEFQ SSIENLQVKL EEFGRPKIDG ELKVRSIVNH TKQDRYLFLF DKVVIVCKRK GYSYELKEII ELLFHKMTDD PMNNKDVKKS HGKMWSYGFY LIHLQGKQGF QFFCKTEDMK RKWMEQFEMA MSNIKPDKAN ANHHSFQMYT FDKTTNCKAC KMFLRGTFYQ GYMCTKCGVG AHKECLEVIP PCKFTSPADL DASGAGPGPK MVAMQNYHGN PAPPGKPVLT FQTGDVLELL RGDPESPWWE GRLVQTRKSG YFPSSSVKPC PVDGRPPISR PPSREIDYTA YPWFAGNMER QQTDNLLKSH ASGTYLIRER PAEAERFAIS IKFNDEVKHI KVVEKDNWIH ITEAKKFDSL LELVEYYQCH SLKESFKQLD TTLKYPYKSR ERSASRASSR SPASCASYNF SFLSPQGLSF ASQGPSAPFW SVFTPRVIGT AVARYNFAAR DMRELSLREG DVVRIYSRIG GDQGWWKGET NGRIGWFPST YVEEEGIQ
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