Beta-chimaerin (CHN2)

About Beta-chimaerin

Beta-chimaerin (CHN2) is a protein from Homo sapiens identified by UniProt accession P52757, 468 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.

Target properties

Protein name	Beta-chimaerin
UniProt accession	P52757
Gene	CHN2
Organism	Homo sapiens
Length	468 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (42)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
gut microbiome measurement · score 0.32
balding measurement · score 0.31
triglyceride measurement · score 0.27
cortical surface area measurement · score 0.24
cortical thickness · score 0.24
PHF-tau measurement · score 0.21
neurofibrillary tangles measurement · score 0.21
hair shape measurement · score 0.21
brain measurement · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P52757-F1	alphafold	PREDICTED	84.71	—

Amino-acid sequence (468 residues)

MAASSNSSLS GSSVSSDAEE YQPPIWKSYL YQLQQEAPRP KRIICPREVE NRPKYYGREF HGIISREQAD ELLGGVEGAY ILRESQRQPG CYTLALRFGN QTLNYRLFHD GKHFVGEKRF ESIHDLVTDG LITLYIETKA AEYISKMTTN PIYEHIGYAT LLREKVSRRL SRSKNEPRKT NVTHEEHTAV EKISSLVRRA ALTHNDNHFN YEKTHNFKVH TFRGPHWCEY CANFMWGLIA QGVRCSDCGL NVHKQCSKHV PNDCQPDLKR IKKVYCCDLT TLVKAHNTQR PMVVDICIRE IEARGLKSEG LYRVSGFTEH IEDVKMAFDR DGEKADISAN VYPDINIITG ALKLYFRDLP IPVITYDTYS KFIDAAKISN ADERLEAVHE VLMLLPPAHY ETLRYLMIHL KKVTMNEKDN FMNAENLGIV FGPTLMRPPE DSTLTTLHDM RYQKLIVQIL IENEDVLF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards