2-iminobutanoate/2-iminopropanoate deaminase (RIDA)

About 2-iminobutanoate/2-iminopropanoate deaminase

2-iminobutanoate/2-iminopropanoate deaminase (RIDA) is a protein from Homo sapiens identified by UniProt accession P52758, 137 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.

Target properties

Protein name	2-iminobutanoate/2-iminopropanoate deaminase
UniProt accession	P52758
Gene	RIDA
Organism	Homo sapiens
Length	137 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (60)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.29
PHF-tau measurement · score 0.17
microcytic anemia with liver iron overload · score 0.05
Adult-onset autosomal recessive sideroblastic anemia · score 0.05
FTH1-related iron overload · score 0.05
hemochromatosis type 5 · score 0.05
Hemolytic anemia due to red cell pyruvate kinase deficiency · score 0.04
hemoglobin D disease · score 0.04
primary familial polycythemia due to EPO receptor mutation · score 0.04
hemolytic anemia due to erythrocyte adenosine deaminase overproduction · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P52758-F1	alphafold	PREDICTED	97.00	—

Amino-acid sequence (137 residues)

MSSLIRRVIS TAKAPGAIGP YSQAVLVDRT IYISGQIGMD PSSGQLVSGG VAEEAKQALK NMGEILKAAG CDFTNVVKTT VLLADINDFN TVNEIYKQYF KSNFPARAAY QVAALPKGSR IEIEAVAIQG PLTTASL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards