About Ephrin-A3
Ephrin-A3 (EFNA3) is a protein
from Homo sapiens identified by UniProt accession
P52797, 238 residues long.
MolForge cross-references it against 0 known binders and
91 disease associations.
Target properties
| Protein name | Ephrin-A3 |
|---|
| UniProt accession | P52797 |
|---|
| Gene | EFNA3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 238 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (91)
Diseases linked to this target (Open Targets).
- serum gamma-glutamyl transferase measurement · score 0.16
- digit length ratio · score 0.14
- non-alcoholic fatty liver disease · score 0.10
- lung adenocarcinoma · score 0.09
- hepatocellular carcinoma · score 0.09
- neoplasm · score 0.08
- gonorrhea · score 0.08
- optic disc size measurement · score 0.06
- cataract · score 0.04
- breast cancer · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P52797-F1 | alphafold | PREDICTED | 73.21 | — |
Amino-acid sequence (238 residues)
MAAAPLLLLL LLVPVPLLPL LAQGPGGALG NRHAVYWNSS NQHLRREGYT VQVNVNDYLD IYCPHYNSSG VGPGAGPGPG GGAEQYVLYM VSRNGYRTCN ASQGFKRWEC NRPHAPHSPI KFSEKFQRYS AFSLGYEFHA GHEYYYISTP THNLHWKCLR MKVFVCCAST SHSGEKPVPT LPQFTMGPNV KINVLEDFEG ENPQVPKLEK SISGTSPKRE HLPLAVGIAF FLMTFLAS
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