About Ephrin-B2
Ephrin-B2 (EFNB2) is a protein
from Homo sapiens identified by UniProt accession
P52799, 333 residues long.
MolForge cross-references it against 0 known binders and
375 disease associations.
Target properties
| Protein name | Ephrin-B2 |
|---|
| UniProt accession | P52799 |
|---|
| Gene | EFNB2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 333 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (375)
Diseases linked to this target (Open Targets).
- cortical surface area measurement · score 0.35
- cortical thickness · score 0.29
- insulin resistance · score 0.23
- diffuse plaque measurement · score 0.15
- facial morphology measurement · score 0.14
- head and neck squamous cell carcinoma · score 0.14
- lung adenocarcinoma · score 0.14
- neoplasm · score 0.12
- insomnia · score 0.12
- total blood protein measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P52799-F1 | alphafold | PREDICTED | 70.82 | — |
Amino-acid sequence (333 residues)
MAVRRDSVWK YCWGVLMVLC RTAISKSIVL EPIYWNSSNS KFLPGQGLVL YPQIGDKLDI ICPKVDSKTV GQYEYYKVYM VDKDQADRCT IKKENTPLLN CAKPDQDIKF TIKFQEFSPN LWGLEFQKNK DYYIISTSNG SLEGLDNQEG GVCQTRAMKI LMKVGQDASS AGSTRNKDPT RRPELEAGTN GRSSTTSPFV KPNPGSSTDG NSAGHSGNNI LGSEVALFAG IASGCIIFIV IIITLVVLLL KYRRRHRKHS PQHTTTLSLS TLATPKRSGN NNGSEPSDII IPLRTADSVF CPHYEKVSGD YGHPVYIVQE MPPQSPANIY YKV
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