About Large ribosomal subunit protein bL12m
Large ribosomal subunit protein bL12m (MRPL12) is a protein
from Homo sapiens identified by UniProt accession
P52815, 198 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | Large ribosomal subunit protein bL12m |
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| UniProt accession | P52815 |
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| Gene | MRPL12 |
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| Organism | Homo sapiens |
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| Length | 198 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (28)
Diseases linked to this target (Open Targets).
- combined oxidative phosphorylation deficiency 45 · score 0.45
- neurodegenerative disease · score 0.38
- lung adenocarcinoma · score 0.08
- acute kidney failure · score 0.06
- hair color · score 0.05
- total blood protein measurement · score 0.05
- hepatocellular carcinoma · score 0.05
- neoplasm · score 0.04
- monocyte count · score 0.03
- creatinine measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P52815-F1 | alphafold | PREDICTED | 66.90 | — |
Amino-acid sequence (198 residues)
MLPAAARPLW GPCLGLRAAA FRLARRQVPC VCAVRHMRSS GHQRCEALAG APLDNAPKEY PPKIQQLVQD IASLTLLEIS DLNELLKKTL KIQDVGLVPM GGVMSGAVPA AAAQEAVEED IPIAKERTHF TVRLTEAKPV DKVKLIKEIK NYIQGINLVQ AKKLVESLPQ EIKANVAKAE AEKIKAALEA VGGTVVLE
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