About Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 (NDST1) is a protein
from Homo sapiens identified by UniProt accession
P52848, 882 residues long.
MolForge cross-references it against 0 known binders and
206 disease associations.
Target properties
| Protein name | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 |
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| UniProt accession | P52848 |
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| Gene | NDST1 |
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| Organism | Homo sapiens |
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| Length | 882 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (206)
Diseases linked to this target (Open Targets).
- autosomal recessive non-syndromic intellectual disability · score 0.57
- Intellectual disability · score 0.40
- BMI-adjusted waist-hip ratio · score 0.28
- leukocyte count · score 0.27
- Global developmental delay · score 0.27
- neutrophil count · score 0.25
- waist-hip ratio · score 0.20
- PHF-tau measurement · score 0.19
- genetic disorder · score 0.19
- appendicular lean mass · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P52848-F1 | alphafold | PREDICTED | 89.98 | — |
Amino-acid sequence (882 residues)
MPALACLRRL CRHVSPQAVL FLLFIFCLFS VFISAYYLYG WKRGLEPSAD APEPDCGDPP PVAPSRLLPL KPVQAATPSR TDPLVLVFVE SLYSQLGQEV VAILESSRFK YRTEIAPGKG DMPTLTDKGR GRFALIIYEN ILKYVNLDAW NRELLDKYCV AYGVGIIGFF KANENSLLSA QLKGFPLFLH SNLGLKDCSI NPKSPLLYVT RPSEVEKGVL PGEDWTVFQS NHSTYEPVLL AKTRSSESIP HLGADAGLHA ALHATVVQDL GLHDGIQRVL FGNNLNFWLH KLVFVDAVAF LTGKRLSLPL DRYILVDIDD IFVGKEGTRM KVEDVKALFD TQNELRAHIP NFTFNLGYSG KFFHTGTNAE DAGDDLLLSY VKEFWWFPHM WSHMQPHLFH NQSVLAEQMA LNKKFAVEHG IPTDMGYAVA PHHSGVYPVH VQLYEAWKQV WSIRVTSTEE YPHLKPARYR RGFIHNGIMV LPRQTCGLFT HTIFYNEYPG GSSELDKIIN GGELFLTVLL NPISIFMTHL SNYGNDRLGL YTFKHLVRFL HSWTNLRLQT LPPVQLAQKY FQIFSEEKDP LWQDPCEDKR HKDIWSKEKT CDRFPKLLII GPQKTGTTAL YLFLGMHPDL SSNYPSSETF EEIQFFNGHN YHKGIDWYME FFPIPSNTTS DFYFEKSANY FDSEVAPRRA AALLPKAKVL TILINPADRA YSWYQHQRAH DDPVALKYTF HEVITAGSDA SSKLRALQNR CLVPGWYATH IERWLSAYHA NQILVLDGKL LRTEPAKVMD MVQKFLGVTN TIDYHKTLAF DPKKGFWCQL LEGGKTKCLG KSKGRKYPEM DLDSRAFLKD YYRDHNIELS KLLYKMGQTL PTWLREDLQN TR
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