About Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 (NDST2) is a protein
from Homo sapiens identified by UniProt accession
P52849, 883 residues long.
MolForge cross-references it against 0 known binders and
121 disease associations.
Target properties
| Protein name | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 |
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| UniProt accession | P52849 |
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| Gene | NDST2 |
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| Organism | Homo sapiens |
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| Length | 883 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (121)
Diseases linked to this target (Open Targets).
- forced expiratory volume · score 0.16
- vital capacity · score 0.13
- atrial fibrillation · score 0.08
- asthma · score 0.08
- atrial flutter · score 0.08
- total blood protein measurement · score 0.07
- C-reactive protein measurement · score 0.07
- neutrophil immunodeficiency syndrome · score 0.07
- myeloperoxidase deficiency · score 0.07
- serum gamma-glutamyl transferase measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P52849-F1 | alphafold | PREDICTED | 90.66 | — |
Amino-acid sequence (883 residues)
MLQLWKVVRP ARQLELHRLI LLLIAFSLGS MGFLAYYVST SPKAKEPLPL PLGDCSSGGA AGPGPARPPV PPRPPRPPET ARTEPVVLVF VESAYSQLGQ EIVAILESSR FRYSTELAPG RGDMPTLTDN THGRYVLVIY ENLLKYVNLD AWSRELLDRY CVEYGVGIIG FFRAHEHSLL SAQLKGFPLF LHSNLGLRDY QVNPSAPLLH LTRPSRLEPG PLPGDDWTIF QSNHSTYEPV LLASLRPAEP AVPGPVLRRA RLPTVVQDLG LHDGIQRVLF GHGLSFWLHK LIFVDAVAYL TGKRLCLDLD RYILVDIDDI FVGKEGTRMK VADVEALLTT QNKLRTLVPN FTFNLGFSGK FYHTGTEEED AGDDMLLKHR KEFWWFPHMW SHMQPHLFHN RSVLADQMRL NKQFALEHGI PTDLGYAVAP HHSGVYPIHT QLYEAWKSVW GIQVTSTEEY PHLRPARYRR GFIHNGIMVL PRQTCGLFTH TIFYNEYPGG SRELDRSIRG GELFLTVLLN PISIFMTHLS NYGNDRLGLY TFESLVRFLQ CWTRLRLQTL PPVPLAQKYF ELFPQERSPL WQNPCDDKRH KDIWSKEKTC DRLPKFLIVG PQKTGTTAIH FFLSLHPAVT SSFPSPSTFE EIQFFNSPNY HKGIDWYMDF FPVPSNASTD FLFEKSATYF DSEVVPRRGA ALLPRAKIIT VLTNPADRAY SWYQHQRAHG DPVALNYTFY QVISASSQTP LALRSLQNRC LVPGYYSTHL QRWLTYYPSG QLLIVDGQEL RTNPAASMES IQKFLGITPF LNYTRTLRFD DDKGFWCQGL EGGKTRCLGR SKGRRYPDMD TESRLFLTDF FRNHNLELSK LLSRLGQPVP SWLREELQHS SLG
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