F-actin-capping protein subunit alpha-1 (CAPZA1)

About F-actin-capping protein subunit alpha-1

F-actin-capping protein subunit alpha-1 (CAPZA1) is a protein from Homo sapiens identified by UniProt accession P52907, 286 residues long. MolForge cross-references it against 0 known binders and 115 disease associations.

Target properties

Protein name	F-actin-capping protein subunit alpha-1
UniProt accession	P52907
Gene	CAPZA1
Organism	Homo sapiens
Length	286 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (115)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
platelet count · score 0.26
diastolic blood pressure · score 0.25
mean platelet volume · score 0.24
systolic blood pressure · score 0.22
platelet component distribution width · score 0.22
platelet crit · score 0.21
heel bone mineral density · score 0.20
breast adenocarcinoma · score 0.18
neuroimaging measurement · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P52907-F1	alphafold	PREDICTED	93.08	—

Amino-acid sequence (286 residues)

MADFDDRVSD EEKVRIAAKF ITHAPPGEFN EVFNDVRLLL NNDNLLREGA AHAFAQYNMD QFTPVKIEGY EDQVLITEHG DLGNSRFLDP RNKISFKFDH LRKEASDPQP EEADGGLKSW RESCDSALRA YVKDHYSNGF CTVYAKTIDG QQTIIACIES HQFQPKNFWN GRWRSEWKFT ITPPTAQVVG VLKIQVHYYE DGNVQLVSHK DVQDSLTVSN EAQTAKEFIK IIENAENEYQ TAISENYQTM SDTTFKALRR QLPVTRTKID WNKILSYKIG KEMQNA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards