High mobility group protein HMGI-C (HMGA2)

About High mobility group protein HMGI-C

High mobility group protein HMGI-C (HMGA2) is a protein from Homo sapiens identified by UniProt accession P52926, 109 residues long. MolForge cross-references it against 0 known binders and 680 disease associations.

Target properties

Protein name	High mobility group protein HMGI-C
UniProt accession	P52926
Gene	HMGA2
Organism	Homo sapiens
Length	109 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (680)

Diseases linked to this target (Open Targets).

Silver-Russell syndrome 5 · score 0.68
body height · score 0.58
lean body mass · score 0.50
type 2 diabetes mellitus · score 0.50
appendicular lean mass · score 0.50
birth weight · score 0.47
sex hormone-binding globulin measurement · score 0.46
diabetes mellitus · score 0.45
fat body mass · score 0.44
systolic blood pressure · score 0.44

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P52926-F1	alphafold	PREDICTED	64.88	—

Amino-acid sequence (109 residues)

MSARGEGAGQ PSTSAQGQPA APAPQKRGRG RPRKQQQEPT GEPSPKRPRG RPKGSKNKSP SKAAQKKAEA TGEKRPRGRP RKWPQQVVQK KPAQEETEET SSQESAEED

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards