Pancreas/duodenum homeobox protein 1 (PDX1)

About Pancreas/duodenum homeobox protein 1

Pancreas/duodenum homeobox protein 1 (PDX1) is a protein from Homo sapiens identified by UniProt accession P52945, 283 residues long. MolForge cross-references it against 0 known binders and 210 disease associations.

Target properties

Protein name	Pancreas/duodenum homeobox protein 1
UniProt accession	P52945
Gene	PDX1
Organism	Homo sapiens
Length	283 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (210)

Diseases linked to this target (Open Targets).

pancreatic agenesis 1 · score 0.72
maturity-onset diabetes of the young type 4 · score 0.71
Partial pancreatic agenesis · score 0.66
MODY · score 0.63
type 2 diabetes mellitus · score 0.52
permanent neonatal diabetes mellitus · score 0.50
maturity-onset diabetes of the young · score 0.48
fasting blood glucose measurement · score 0.41
glucose measurement · score 0.38
serum gamma-glutamyl transferase measurement · score 0.36

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P52945-F1	alphafold	PREDICTED	64.11	—

Amino-acid sequence (283 residues)

MNGEEQYYAA TQLYKDPCAF QRGPAPEFSA SPPACLYMGR QPPPPPPHPF PGALGALEQG SPPDISPYEV PPLADDPAVA HLHHHLPAQL ALPHPPAGPF PEGAEPGVLE EPNRVQLPFP WMKSTKAHAW KGQWAGGAYA AEPEENKRTR TAYTRAQLLE LEKEFLFNKY ISRPRRVELA VMLNLTERHI KIWFQNRRMK WKKEEDKKRG GGTAVGGGGV AEPEQDCAVT SGEELLALPP PPPPGGAVPP AAPVAAREGR LPPGLSASPQ PSSVAPRRPQ EPR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards