Homeobox protein GBX-2 (GBX2)

About Homeobox protein GBX-2

Homeobox protein GBX-2 (GBX2) is a protein from Homo sapiens identified by UniProt accession P52951, 348 residues long. MolForge cross-references it against 0 known binders and 106 disease associations.

Target properties

Protein name	Homeobox protein GBX-2
UniProt accession	P52951
Gene	GBX2
Organism	Homo sapiens
Length	348 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (106)

Diseases linked to this target (Open Targets).

self reported educational attainment · score 0.36
neurodegenerative disease · score 0.28
mathematical ability · score 0.27
schizophrenia · score 0.26
intelligence · score 0.24
drug use measurement · score 0.23
body mass index · score 0.11
lean body mass · score 0.11
lymphocyte count · score 0.10
adolescent idiopathic scoliosis · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P52951-F1	alphafold	PREDICTED	61.74	—

Amino-acid sequence (348 residues)

MSAAFPPSLM MMQRPLGSST AFSIDSLIGS PPQPSPGHFV YTGYPMFMPY RPVVLPPPPP PPPALPQAAL QPALPPAHPH HQIPSLPTGF CSSLAQGMAL TSTLMATLPG GFSASPQHQE AAAARKFAPQ PLPGGGNFDK AEALQADAED GKGFLAKEGS LLAFSAAETV QASLVGAVRG QGKDESKVED DPKGKEESFS LESDVDYSSD DNLTGQAAHK EEDPGHALEE TPPSSGAAGS TTSTGKNRRR RTAFTSEQLL ELEKEFHCKK YLSLTERSQI AHALKLSEVQ VKIWFQNRRA KWKRVKAGNA NSKTGEPSRN PKIVVPIPVH VSRFAIRSQH QQLEQARP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards