About Homeobox protein Nkx-2.5
Homeobox protein Nkx-2.5 (NKX2-5) is a protein
from Homo sapiens identified by UniProt accession
P52952, 324 residues long.
MolForge cross-references it against 0 known binders and
543 disease associations.
Target properties
| Protein name | Homeobox protein Nkx-2.5 |
|---|
| UniProt accession | P52952 |
|---|
| Gene | NKX2-5 |
|---|
| Organism | Homo sapiens |
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| Length | 324 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (543)
Diseases linked to this target (Open Targets).
- atrial septal defect 7 · score 0.85
- Atrial septal defect - atrioventricular conduction defects · score 0.83
- Tetralogy of Fallot · score 0.77
- hypothyroidism, congenital, nongoitrous, 5 · score 0.73
- ventricular septal defect 3 · score 0.69
- atrial heart septal defect · score 0.65
- hypoplastic left heart syndrome 2 · score 0.64
- congenital heart disease · score 0.55
- conotruncal heart malformations · score 0.53
- neurodegenerative disease · score 0.51
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P52952-F1 | alphafold | PREDICTED | 62.55 | — |
Amino-acid sequence (324 residues)
MFPSPALTPT PFSVKDILNL EQQQRSLAAA GELSARLEAT LAPSSCMLAA FKPEAYAGPE AAAPGLPELR AELGRAPSPA KCASAFPAAP AFYPRAYSDP DPAKDPRAEK KELCALQKAV ELEKTEADNA ERPRARRRRK PRVLFSQAQV YELERRFKQQ RYLSAPERDQ LASVLKLTST QVKIWFQNRR YKCKRQRQDQ TLELVGLPPP PPPPARRIAV PVLVRDGKPC LGDSAPYAPA YGVGLNPYGY NAYPAYPGYG GAACSPGYSC TAAYPAGPSP AQPATAAANN NFVNFGVGDL NAVQSPGIPQ SNSGVSTLHG IRAW
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