About Transcription factor LBX1
Transcription factor LBX1 (LBX1) is a protein
from Homo sapiens identified by UniProt accession
P52954, 281 residues long.
MolForge cross-references it against 0 known binders and
255 disease associations.
Target properties
| Protein name | Transcription factor LBX1 |
|---|
| UniProt accession | P52954 |
|---|
| Gene | LBX1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 281 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (255)
Diseases linked to this target (Open Targets).
- central hypoventilation syndrome, congenital, 1, with or without Hirschsprung disease · score 0.37
- adolescent idiopathic scoliosis · score 0.32
- mean corpuscular volume · score 0.28
- scoliosis · score 0.21
- type 2 diabetes mellitus · score 0.11
- cystatin C measurement · score 0.10
- oral squamous cell carcinoma · score 0.08
- Åland Islands eye disease · score 0.05
- congenital diaphragmatic hernia · score 0.05
- craniofacial conodysplasia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P52954-F1 | alphafold | PREDICTED | 66.87 | — |
Amino-acid sequence (281 residues)
MTSKEDGKAA PGEERRRSPL DHLPPPANSN KPLTPFSIED ILNKPSVRRS YSLCGAAHLL AAADKHAQGG LPLAGRALLS QTSPLCALEE LASKTFKGLE VSVLQAAEGR DGMTIFGQRQ TPKKRRKSRT AFTNHQIYEL EKRFLYQKYL SPADRDQIAQ QLGLTNAQVI TWFQNRRAKL KRDLEEMKAD VESAKKLGPS GQMDIVALAE LEQNSEATAG GGGGCGRAKS RPGSPVLPPG APKAPGAGAL QLSPASPLTD QPASSQDCSE DEEDEEIDVD D
Explore Transcription factor LBX1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets