Biliverdin reductase A (BLVRA)

About Biliverdin reductase A

Biliverdin reductase A (BLVRA) is a protein from Homo sapiens identified by UniProt accession P53004, 296 residues long. MolForge cross-references it against 0 known binders and 153 disease associations.

Target properties

Protein name	Biliverdin reductase A
UniProt accession	P53004
Gene	BLVRA
Organism	Homo sapiens
Length	296 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (153)

Diseases linked to this target (Open Targets).

hyperbiliverdinemia · score 0.58
neurodegenerative disease · score 0.31
mean corpuscular volume · score 0.31
neurofibrillary tangles measurement · score 0.22
peak insulin response measurement · score 0.19
brain measurement · score 0.16
cortical surface area measurement · score 0.15
urate measurement · score 0.14
gut microbiome measurement · score 0.12
pulmonary non-tuberculous mycobacterial infection · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P53004-F1	alphafold	PREDICTED	95.89	—

Amino-acid sequence (296 residues)

MNAEPERKFG VVVVGVGRAG SVRMRDLRNP HPSSAFLNLI GFVSRRELGS IDGVQQISLE DALSSQEVEV AYICSESSSH EDYIRQFLNA GKHVLVEYPM TLSLAAAQEL WELAEQKGKV LHEEHVELLM EEFAFLKKEV VGKDLLKGSL LFTAGPLEEE RFGFPAFSGI SRLTWLVSLF GELSLVSATL EERKEDQYMK MTVCLETEKK SPLSWIEEKG PGLKRNRYLS FHFKSGSLEN VPNVGVNKNI FLKDQNIFVQ KLLGQFSEKE LAAEKKRILH CLGLAEEIQK YCCSRK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards