Serine/threonine-protein phosphatase 5 (PPP5C)

About Serine/threonine-protein phosphatase 5

Serine/threonine-protein phosphatase 5 (PPP5C) is a protein from Homo sapiens identified by UniProt accession P53041, 499 residues long. MolForge cross-references it against 0 known binders and 98 disease associations.

Target properties

Protein name	Serine/threonine-protein phosphatase 5
UniProt accession	P53041
Gene	PPP5C
Organism	Homo sapiens
Length	499 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (98)

Diseases linked to this target (Open Targets).

hemoglobin measurement · score 0.35
lymphocyte count · score 0.33
eosinophil count · score 0.32
Crohn's disease · score 0.31
triglyceride measurement · score 0.31
breast adenocarcinoma · score 0.29
eosinophil percentage of leukocytes · score 0.29
erythrocyte count · score 0.27
monocyte count · score 0.27
neurodegenerative disease · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P53041-F1	alphafold	PREDICTED	92.77	—

Amino-acid sequence (499 residues)

MAMAEGERTE CAEPPRDEPP ADGALKRAEE LKTQANDYFK AKDYENAIKF YSQAIELNPS NAIYYGNRSL AYLRTECYGY ALGDATRAIE LDKKYIKGYY RRAASNMALG KFRAALRDYE TVVKVKPHDK DAKMKYQECN KIVKQKAFER AIAGDEHKRS VVDSLDIESM TIEDEYSGPK LEDGKVTISF MKELMQWYKD QKKLHRKCAY QILVQVKEVL SKLSTLVETT LKETEKITVC GDTHGQFYDL LNIFELNGLP SETNPYIFNG DFVDRGSFSV EVILTLFGFK LLYPDHFHLL RGNHETDNMN QIYGFEGEVK AKYTAQMYEL FSEVFEWLPL AQCINGKVLI MHGGLFSEDG VTLDDIRKIE RNRQPPDSGP MCDLLWSDPQ PQNGRSISKR GVSCQFGPDV TKAFLEENNL DYIIRSHEVK AEGYEVAHGG RCVTVFSAPN YCDQMGNKAS YIHLQGSDLR PQFHQFTAVP HPNVKPMAYA NTLLQLGMM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards