Arfaptin-2 (ARFIP2)

About Arfaptin-2

Arfaptin-2 (ARFIP2) is a protein from Homo sapiens identified by UniProt accession P53365, 341 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.

Target properties

Protein name	Arfaptin-2
UniProt accession	P53365
Gene	ARFIP2
Organism	Homo sapiens
Length	341 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (40)

Diseases linked to this target (Open Targets).

hepatocellular carcinoma · score 0.08
nephrotic syndrome · score 0.06
familial idiopathic steroid-resistant nephrotic syndrome · score 0.06
focal segmental glomerulosclerosis · score 0.05
neoplasm · score 0.05
proteinuria, chronic benign · score 0.04
focal segmental glomerulosclerosis 7 · score 0.04
nephrotic syndrome 16 · score 0.04
Dent disease · score 0.04
nail-patella-like renal disease · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P53365-F1	alphafold	PREDICTED	80.71	—

Amino-acid sequence (341 residues)

MTDGILGKAA TMEIPIHGNG EARQLPEDDG LEQDLQQVMV SGPNLNETSI VSGGYGGSGD GLIPTGSGRH PSHSTTPSGP GDEVARGIAG EKFDIVKKWG INTYKCTKQL LSERFGRGSR TVDLELELQI ELLRETKRKY ESVLQLGRAL TAHLYSLLQT QHALGDAFAD LSQKSPELQE EFGYNAETQK LLCKNGETLL GAVNFFVSSI NTLVTKTMED TLMTVKQYEA ARLEYDAYRT DLEELSLGPR DAGTRGRLES AQATFQAHRD KYEKLRGDVA IKLKFLEENK IKVMHKQLLL FHNAVSAYFA GNQKQLEQTL QQFNIKLRPP GAEKPSWLEE Q

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards