Arfaptin-1 (ARFIP1)

About Arfaptin-1

Arfaptin-1 (ARFIP1) is a protein from Homo sapiens identified by UniProt accession P53367, 373 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.

Target properties

Protein name	Arfaptin-1
UniProt accession	P53367
Gene	ARFIP1
Organism	Homo sapiens
Length	373 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (15)

Diseases linked to this target (Open Targets).

Red cell distribution width · score 0.45
mean corpuscular hemoglobin concentration · score 0.43
reticulocyte count · score 0.41
mean platelet volume · score 0.40
FEV/FVC ratio · score 0.37
reticulocyte measurement · score 0.36
lower respiratory tract disease · score 0.27
HbA1c measurement · score 0.26
mean corpuscular volume · score 0.20
protein measurement · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P53367-F1	alphafold	PREDICTED	75.52	—

Amino-acid sequence (373 residues)

MAQESPKNSA AEIPVTSNGE VDDSREHSFN RDLKHSLPSG LGLSETQITS HGFDNTKEGV IEAGAFQGSP APPLPSVMSP SRVAASRLAQ QGSDLIVPAG GQRTQTKSGP VILADEIKNP AMEKLELVRK WSLNTYKCTR QIISEKLGRG SRTVDLELEA QIDILRDNKK KYENILKLAQ TLSTQLFQMV HTQRQLGDAF ADLSLKSLEL HEEFGYNADT QKLLAKNGET LLGAINFFIA SVNTLVNKTI EDTLMTVKQY ESARIEYDAY RTDLEELNLG PRDANTLPKI EQSQHLFQAH KEKYDKMRND VSVKLKFLEE NKVKVLHNQL VLFHNAIAAY FAGNQKQLEQ TLKQFHIKLK TPGVDAPSWL EEQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards