Protein FosB (FOSB)

About Protein FosB

Protein FosB (FOSB) is a protein from Homo sapiens identified by UniProt accession P53539, 338 residues long. MolForge cross-references it against 0 known binders and 362 disease associations.

Target properties

Protein name	Protein FosB
UniProt accession	P53539
Gene	FOSB
Organism	Homo sapiens
Length	338 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (362)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.22
heel bone mineral density · score 0.21
triple-negative breast cancer · score 0.10
generalised epilepsy · score 0.10
Benign familial neonatal seizures · score 0.10
neoplasm · score 0.09
X-linked non-syndromic intellectual disability · score 0.09
juvenile myoclonic epilepsy · score 0.09
non-small cell lung carcinoma · score 0.09
attention deficit hyperactivity disorder · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P53539-F1	alphafold	PREDICTED	59.13	—

Amino-acid sequence (338 residues)

MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM PGSFVPTVTA ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPVVDPYDMP GTSYSTPGMS GYSSGGASGS GGPSTSGTTS GPGPARPARA RPRRPREETL TPEEEEKRRV RRERNKLAAA KCRNRRRELT DRLQAETDQL EEEKAELESE IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD LPGSAPAKED GFSWLLPPPP PPPLPFQTSQ DAPPNLTASL FTHSEVQVLG DPFPVVNPSY TSSFVLTCPE VSAFAGAQRT SGSDQPSDPL NSPSLLAL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards