Diphosphomevalonate decarboxylase (MVD)

About Diphosphomevalonate decarboxylase

Diphosphomevalonate decarboxylase (MVD) is a protein from Homo sapiens identified by UniProt accession P53602, 400 residues long. MolForge cross-references it against 0 known binders and 79 disease associations.

Target properties

Protein name	Diphosphomevalonate decarboxylase
UniProt accession	P53602
Gene	MVD
Organism	Homo sapiens
Length	400 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (79)

Diseases linked to this target (Open Targets).

disseminated superficial actinic porokeratosis · score 0.66
neurodegenerative disease · score 0.55
linear porokeratosis · score 0.32
lysosomal storage disease · score 0.27
mean corpuscular hemoglobin · score 0.16
mean corpuscular volume · score 0.15
genetic disorder · score 0.12
airway imaging measurement · score 0.11
Griscelli syndrome type 3 · score 0.06
Griscelli disease · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P53602-F1	alphafold	PREDICTED	92.15	—

Amino-acid sequence (400 residues)

MASEKPLAAV TCTAPVNIAV IKYWGKRDEE LVLPINSSLS VTLHQDQLKT TTTAVISKDF TEDRIWLNGR EEDVGQPRLQ ACLREIRCLA RKRRNSRDGD PLPSSLSCKV HVASVNNFPT AAGLASSAAG YACLAYTLAR VYGVESDLSE VARRGSGSAC RSLYGGFVEW QMGEQADGKD SIARQVAPES HWPELRVLIL VVSAEKKLTG STVGMRASVE TSPLLRFRAE SVVPARMAEM ARCIRERDFP SFAQLTMKDS NQFHATCLDT FPPISYLNAI SWRIIHLVHR FNAHHGDTKV AYTFDAGPNA VIFTLDDTVA EFVAAVWHGF PPGSNGDTFL KGLQVRPAPL SAELQAALAM EPTPGGVKYI IVTQVGPGPQ ILDDPCAHLL GPDGLPKPAA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards