About LIM domain kinase 1
LIM domain kinase 1 (LIMK1) is a protein
from Homo sapiens identified by UniProt accession
P53667, 647 residues long.
MolForge cross-references it against 0 known binders and
197 disease associations.
Target properties
| Protein name | LIM domain kinase 1 |
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| UniProt accession | P53667 |
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| Gene | LIMK1 |
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| Organism | Homo sapiens |
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| Length | 647 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (12)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (197)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- undetermined early-onset epileptic encephalopathy · score 0.33
- FEV/FVC ratio · score 0.29
- monocyte count · score 0.26
- total blood protein measurement · score 0.24
- pulse pressure measurement · score 0.23
- endometrial cancer · score 0.21
- breast adenocarcinoma · score 0.18
- skin aging measurement · score 0.17
- head and neck squamous cell carcinoma · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P53667-F1 | alphafold | PREDICTED | 75.19 | — |
Amino-acid sequence (647 residues)
MRLTLLCCTW REERMGEEGS ELPVCASCGQ RIYDGQYLQA LNADWHADCF RCCDCSASLS HQYYEKDGQL FCKKDYWARY GESCHGCSEQ ITKGLVMVAG ELKYHPECFI CLTCGTFIGD GDTYTLVEHS KLYCGHCYYQ TVVTPVIEQI LPDSPGSHLP HTVTLVSIPA SSHGKRGLSV SIDPPHGPPG CGTEHSHTVR VQGVDPGCMS PDVKNSIHVG DRILEINGTP IRNVPLDEID LLIQETSRLL QLTLEHDPHD TLGHGLGPET SPLSSPAYTP SGEAGSSARQ KPVLRSCSID RSPGAGSLGS PASQRKDLGR SESLRVVCRP HRIFRPSDLI HGEVLGKGCF GQAIKVTHRE TGEVMVMKEL IRFDEETQRT FLKEVKVMRC LEHPNVLKFI GVLYKDKRLN FITEYIKGGT LRGIIKSMDS QYPWSQRVSF AKDIASGMAY LHSMNIIHRD LNSHNCLVRE NKNVVVADFG LARLMVDEKT QPEGLRSLKK PDRKKRYTVV GNPYWMAPEM INGRSYDEKV DVFSFGIVLC EIIGRVNADP DYLPRTMDFG LNVRGFLDRY CPPNCPPSFF PITVRCCDLD PEKRPSFVKL EHWLETLRMH LAGHLPLGPQ LEQLDRGFWE TYRRGESGLP AHPEVPD
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