About LIM domain kinase 2
LIM domain kinase 2 (LIMK2) is a protein
from Homo sapiens identified by UniProt accession
P53671, 638 residues long.
MolForge cross-references it against 0 known binders and
219 disease associations.
Target properties
| Protein name | LIM domain kinase 2 |
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| UniProt accession | P53671 |
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| Gene | LIMK2 |
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| Organism | Homo sapiens |
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| Length | 638 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (10)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (219)
Diseases linked to this target (Open Targets).
- neuroinflammatory disorder · score 0.37
- Red cell distribution width · score 0.28
- eosinophil count · score 0.28
- neutrophil count · score 0.26
- leukocyte count · score 0.25
- eosinophil percentage of leukocytes · score 0.19
- body height · score 0.19
- sum of eosinophil and basophil counts · score 0.13
- reticulocyte measurement · score 0.13
- eosinophil percentage of granulocytes · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P53671-F1 | alphafold | PREDICTED | 76.18 | — |
Amino-acid sequence (638 residues)
MSALAGEDVW RCPGCGDHIA PSQIWYRTVN ETWHGSCFRC SECQDSLTNW YYEKDGKLYC PKDYWGKFGE FCHGCSLLMT GPFMVAGEFK YHPECFACMS CKVIIEDGDA YALVQHATLY CGKCHNEVVL APMFERLSTE SVQEQLPYSV TLISMPATTE GRRGFSVSVE SACSNYATTV QVKEVNRMHI SPNNRNAIHP GDRILEINGT PVRTLRVEEV EDAISQTSQT LQLLIEHDPV SQRLDQLRLE ARLAPHMQNA GHPHALSTLD TKENLEGTLR RRSLRRSNSI SKSPGPSSPK EPLLFSRDIS RSESLRCSSS YSQQIFRPCD LIHGEVLGKG FFGQAIKVTH KATGKVMVMK ELIRCDEETQ KTFLTEVKVM RSLDHPNVLK FIGVLYKDKK LNLLTEYIEG GTLKDFLRSM DPFPWQQKVR FAKGIASGMA YLHSMCIIHR DLNSHNCLIK LDKTVVVADF GLSRLIVEER KRAPMEKATT KKRTLRKNDR KKRYTVVGNP YWMAPEMLNG KSYDETVDIF SFGIVLCEII GQVYADPDCL PRTLDFGLNV KLFWEKFVPT DCPPAFFPLA AICCRLEPES RPAFSKLEDS FEALSLYLGE LGIPLPAELE ELDHTVSMQY GLTRDSPP
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