About Beta-crystallin A2
Beta-crystallin A2 (CRYBA2) is a protein
from Homo sapiens identified by UniProt accession
P53672, 197 residues long.
MolForge cross-references it against 0 known binders and
160 disease associations.
Target properties
| Protein name | Beta-crystallin A2 |
|---|
| UniProt accession | P53672 |
|---|
| Gene | CRYBA2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 197 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (160)
Diseases linked to this target (Open Targets).
- cataract · score 0.39
- early-onset anterior polar cataract · score 0.37
- early-onset nuclear cataract · score 0.37
- tooth agenesis · score 0.17
- type 2 diabetes mellitus · score 0.14
- neutrophil percentage of leukocytes · score 0.13
- body height · score 0.13
- response to statin · score 0.13
- early-onset non-syndromic cataract · score 0.11
- cataract 13 with adult I phenotype · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P53672-F1 | alphafold | PREDICTED | 92.56 | — |
Amino-acid sequence (197 residues)
MSSAPAPGPA PASLTLWDEE DFQGRRCRLL SDCANVCERG GLPRVRSVKV ENGVWVAFEY PDFQGQQFIL EKGDYPRWSA WSGSSSHNSN QLLSFRPVLC ANHNDSRVTL FEGDNFQGCK FDLVDDYPSL PSMGWASKDV GSLKVSSGAW VAYQYPGYRG YQYVLERDRH SGEFCTYGEL GTQAHTGQLQ SIRRVQH
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