About Beta-crystallin A4
Beta-crystallin A4 (CRYBA4) is a protein
from Homo sapiens identified by UniProt accession
P53673, 196 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Beta-crystallin A4 |
|---|
| UniProt accession | P53673 |
|---|
| Gene | CRYBA4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 196 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (33)
Diseases linked to this target (Open Targets).
- early-onset non-syndromic cataract · score 0.65
- cataract · score 0.50
- Cataract-microcornea syndrome · score 0.37
- leukocyte count · score 0.29
- myeloid white cell count · score 0.29
- cognitive function measurement · score 0.17
- diet measurement · score 0.17
- mathematical ability · score 0.17
- genetic disorder · score 0.17
- self reported educational attainment · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P53673-F1 | alphafold | PREDICTED | 91.14 | — |
Amino-acid sequence (196 residues)
MTLQCTKSAG PWKMVVWDED GFQGRRHEFT AECPSVLELG FETVRSLKVL SGAWVGFEHA GFQGQQYILE RGEYPSWDAW GGNTAYPAER LTSFRPAACA NHRDSRLTIF EQENFLGKKG ELSDDYPSLQ AMGWEGNEVG SFHVHSGAWV CSQFPGYRGF QYVLECDHHS GDYKHFREWG SHAPTFQVQS IRRIQQ
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