About Beta-crystallin B1
Beta-crystallin B1 (CRYBB1) is a protein
from Homo sapiens identified by UniProt accession
P53674, 252 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | Beta-crystallin B1 |
|---|
| UniProt accession | P53674 |
|---|
| Gene | CRYBB1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 252 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (53)
Diseases linked to this target (Open Targets).
- early-onset non-syndromic cataract · score 0.53
- Cataract-microcornea syndrome · score 0.37
- early-onset nuclear cataract · score 0.37
- pulverulent cataract · score 0.37
- neurodegenerative disease · score 0.35
- Developmental cataract · score 0.29
- genetic disorder · score 0.19
- cognitive function measurement · score 0.14
- diet measurement · score 0.14
- mathematical ability · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P53674-F1 | alphafold | PREDICTED | 79.89 | — |
Amino-acid sequence (252 residues)
MSQAAKASAS ATVAVNPGPD TKGKGAPPAG TSPSPGTTLA PTTVPITSAK AAELPPGNYR LVVFELENFQ GRRAEFSGEC SNLADRGFDR VRSIIVSAGP WVAFEQSNFR GEMFILEKGE YPRWNTWSSS YRSDRLMSFR PIKMDAQEHK ISLFEGANFK GNTIEIQGDD APSLWVYGFS DRVGSVKVSS GTWVGYQYPG YRGYQYLLEP GDFRHWNEWG AFQPQMQSLR RLRDKQWHLE GSFPVLATEP PK
Explore Beta-crystallin B1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets