AP-3 complex subunit mu-2 (AP3M2)

About AP-3 complex subunit mu-2

AP-3 complex subunit mu-2 (AP3M2) is a protein from Homo sapiens identified by UniProt accession P53677, 418 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	AP-3 complex subunit mu-2
UniProt accession	P53677
Gene	AP3M2
Organism	Homo sapiens
Length	418 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (52)

Diseases linked to this target (Open Targets).

hair color · score 0.18
skin pigmentation · score 0.16
blood protein measurement · score 0.13
juvenile myoclonic epilepsy · score 0.06
Generalized epilepsy with febrile seizures-plus · score 0.06
generalised epilepsy · score 0.06
developmental and epileptic encephalopathy 94 · score 0.05
Jeavons syndrome · score 0.05
developmental and epileptic encephalopathy, 9 · score 0.04
developmental and epileptic encephalopathy, 19 · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P53677-F1	alphafold	PREDICTED	92.79	—

Amino-acid sequence (418 residues)

MIHSLFLINS SGDIFLEKHW KSVVSRSVCD YFFEAQERAT EAENVPPVIP TPHHYLLSVY RHKIFFVAVI QTEVPPLFVI EFLHRVVDTF QDYFGVCSEP VIKDNVVVVY EVLEEMLDNG FPLATESNIL KELIKPPTIL RTVVNTITGS TNVGDQLPTG QLSVVPWRRT GVKYTNNEAY FDVIEEIDAI IDKSGSTITA EIQGVIDACV KLTGMPDLTL SFMNPRLLDD VSFHPCVRFK RWESERILSF IPPDGNFRLL SYHVSAQNLV AIPVYVKHNI SFRDSSSLGR FEITVGPKQT MGKTIEGVTV TSQMPKGVLN MSLTPSQGTH TFDPVTKMLS WDVGKINPQK LPSLKGTMSL QAGASKPDEN PTINLQFKIQ QLAISGLKVN RLDMYGEKYK PFKGIKYMTK AGKFQVRT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards