About AP-2 complex subunit sigma
AP-2 complex subunit sigma (AP2S1) is a protein
from Homo sapiens identified by UniProt accession
P53680, 142 residues long.
MolForge cross-references it against 0 known binders and
66 disease associations.
Target properties
| Protein name | AP-2 complex subunit sigma |
|---|
| UniProt accession | P53680 |
|---|
| Gene | AP2S1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 142 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (66)
Diseases linked to this target (Open Targets).
- familial hypocalciuric hypercalcemia 3 · score 0.68
- Familial hypocalciuric hypercalcemia type 3 · score 0.67
- neurodegenerative disease · score 0.55
- HIV infection · score 0.55
- familial hypocalciuric hypercalcemia · score 0.49
- Alzheimer disease · score 0.46
- multiple sclerosis · score 0.46
- lysosomal storage disease · score 0.46
- Parkinson disease · score 0.46
- Neurodevelopmental disorder · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P53680-F1 | alphafold | PREDICTED | 97.00 | — |
Amino-acid sequence (142 residues)
MIRFILIQNR AGKTRLAKWY MQFDDDEKQK LIEEVHAVVT VRDAKHTNFV EFRNFKIIYR RYAGLYFCIC VDVNDNNLAY LEAIHNFVEV LNEYFHNVCE LDLVFNFYKV YTVVDEMFLA GEIRETSQTK VLKQLLMLQS LE
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