Holocytochrome c-type synthase (HCCS)

About Holocytochrome c-type synthase

Holocytochrome c-type synthase (HCCS) is a protein from Homo sapiens identified by UniProt accession P53701, 268 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.

Target properties

Protein name	Holocytochrome c-type synthase
UniProt accession	P53701
Gene	HCCS
Organism	Homo sapiens
Length	268 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (44)

Diseases linked to this target (Open Targets).

Microphthalmia with linear skin defects syndrome · score 0.80
neurodegenerative disease · score 0.52
lysosomal storage disease · score 0.27
genetic disorder · score 0.17
male reproductive organ cancer · score 0.12
microphthalmia · score 0.03
prostate carcinoma · score 0.03
neoplasm · score 0.02
axial length measurement · score 0.02
linear skin defects with multiple congenital anomalies · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P53701-F1	alphafold	PREDICTED	77.34	—

Amino-acid sequence (268 residues)

MGLSPSAPAV AVQASNASAS PPSGCPMHEG KMKGCPVNTE PSGPTCEKKT YSVPAHQERA YEYVECPIRG TAAENKENLD PSNLMPPPNQ TPAPDQPFAL STVREESSIP RADSEKKWVY PSEQMFWNAM LKKGWKWKDE DISQKDMYNI IRIHNQNNEQ AWKEILKWEA LHAAECPCGP SLIRFGGKAK EYSPRARIRS WMGYELPFDR HDWIINRCGT EVRYVIDYYD GGEVNKDYQF TILDVRPALD SLSAVWDRMK VAWWRWTS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards