About Mitogen-activated protein kinase 12
Mitogen-activated protein kinase 12 (MAPK12) is a protein
from Homo sapiens identified by UniProt accession
P53778, 367 residues long.
MolForge cross-references it against 0 known binders and
82 disease associations.
Target properties
| Protein name | Mitogen-activated protein kinase 12 |
|---|
| UniProt accession | P53778 |
|---|
| Gene | MAPK12 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 367 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (82)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- cutaneous melanoma · score 0.23
- neuroinflammatory disorder · score 0.17
- drug use measurement · score 0.09
- neoplasm · score 0.08
- cancer · score 0.08
- platelet count · score 0.06
- platelet crit · score 0.06
- sex hormone-binding globulin measurement · score 0.06
- triglyceride measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P53778-F1 | alphafold | PREDICTED | 88.03 | — |
Amino-acid sequence (367 residues)
MSSPPPARSG FYRQEVTKTA WEVRAVYRDL QPVGSGAYGA VCSAVDGRTG AKVAIKKLYR PFQSELFAKR AYRELRLLKH MRHENVIGLL DVFTPDETLD DFTDFYLVMP FMGTDLGKLM KHEKLGEDRI QFLVYQMLKG LRYIHAAGII HRDLKPGNLA VNEDCELKIL DFGLARQADS EMTGYVVTRW YRAPEVILNW MRYTQTVDIW SVGCIMAEMI TGKTLFKGSD HLDQLKEIMK VTGTPPAEFV QRLQSDEAKN YMKGLPELEK KDFASILTNA SPLAVNLLEK MLVLDAEQRV TAGEALAHPY FESLHDTEDE PQVQKYDDSF DDVDRTLDEW KRVTYKEVLS FKPPRQLGAR VSKETPL
Explore Mitogen-activated protein kinase 12 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets