About Mitogen-activated protein kinase 10
Mitogen-activated protein kinase 10 (MAPK10) is a protein
from Homo sapiens identified by UniProt accession
P53779, 464 residues long.
MolForge cross-references it against 0 known binders and
212 disease associations.
Target properties
| Protein name | Mitogen-activated protein kinase 10 |
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| UniProt accession | P53779 |
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| Gene | MAPK10 |
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| Organism | Homo sapiens |
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| Length | 464 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (212)
Diseases linked to this target (Open Targets).
- triglyceride measurement · score 0.33
- hearing loss · score 0.33
- urate measurement · score 0.28
- PHF-tau measurement · score 0.27
- breast adenocarcinoma · score 0.25
- Lennox-Gastaut syndrome · score 0.25
- gut microbiome measurement · score 0.23
- thyroid gland adenocarcinoma · score 0.23
- Epileptic encephalopathy · score 0.22
- head and neck squamous cell carcinoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P53779-F1 | alphafold | PREDICTED | 79.32 | — |
Amino-acid sequence (464 residues)
MSLHFLYYCS EPTLDVKIAF CQGFDKQVDV SYIAKHYNMS KSKVDNQFYS VEVGDSTFTV LKRYQNLKPI GSGAQGIVCA AYDAVLDRNV AIKKLSRPFQ NQTHAKRAYR ELVLMKCVNH KNIISLLNVF TPQKTLEEFQ DVYLVMELMD ANLCQVIQME LDHERMSYLL YQMLCGIKHL HSAGIIHRDL KPSNIVVKSD CTLKILDFGL ARTAGTSFMM TPYVVTRYYR APEVILGMGY KENVDIWSVG CIMGEMVRHK ILFPGRDYID QWNKVIEQLG TPCPEFMKKL QPTVRNYVEN RPKYAGLTFP KLFPDSLFPA DSEHNKLKAS QARDLLSKML VIDPAKRISV DDALQHPYIN VWYDPAEVEA PPPQIYDKQL DEREHTIEEW KELIYKEVMN SEEKTKNGVV KGQPSPSGAA VNSSESLPPS SSVNDISSMS TDQTLASDTD SSLEASAGPL GCCR
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