About Sodium/myo-inositol cotransporter
Sodium/myo-inositol cotransporter (SLC5A3) is a protein
from Homo sapiens identified by UniProt accession
P53794, 718 residues long.
MolForge cross-references it against 0 known binders and
126 disease associations.
Target properties
| Protein name | Sodium/myo-inositol cotransporter |
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| UniProt accession | P53794 |
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| Gene | SLC5A3 |
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| Organism | Homo sapiens |
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| Length | 718 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (126)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- cystatin C measurement · score 0.36
- creatinine measurement · score 0.32
- erythrocyte count · score 0.32
- hemoglobin measurement · score 0.31
- BMI-adjusted waist-hip ratio · score 0.30
- platelet count · score 0.30
- coronary artery disease · score 0.30
- heel bone mineral density · score 0.29
- myocardial infarction · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P53794-F1 | alphafold | PREDICTED | 78.65 | — |
Amino-acid sequence (718 residues)
MRAVLDTADI AIVALYFILV MCIGFFAMWK SNRSTVSGYF LAGRSMTWVA IGASLFVSNI GSEHFIGLAG SGAASGFAVG AWEFNALLLL QLLGWVFIPI YIRSGVYTMP EYLSKRFGGH RIQVYFAALS LILYIFTKLS VDLYSGALFI QESLGWNLYV SVILLIGMTA LLTVTGGLVA VIYTDTLQAL LMIIGALTLM IISIMEIGGF EEVKRRYMLA SPDVTSILLT YNLSNTNSCN VSPKKEALKM LRNPTDEDVP WPGFILGQTP ASVWYWCADQ VIVQRVLAAK NIAHAKGSTL MAGFLKLLPM FIIVVPGMIS RILFTDDIAC INPEHCMLVC GSRAGCSNIA YPRLVMKLVP VGLRGLMMAV MIAALMSDLD SIFNSASTIF TLDVYKLIRK SASSRELMIV GRIFVAFMVV ISIAWVPIIV EMQGGQMYLY IQEVADYLTP PVAALFLLAI FWKRCNEQGA FYGGMAGFVL GAVRLILAFA YRAPECDQPD NRPGFIKDIH YMYVATGLFW VTGLITVIVS LLTPPPTKEQ IRTTTFWSKK NLVVKENCSP KEEPYKMQEK SILRCSENNE TINHIIPNGK SEDSIKGLQP EDVNLLVTCR EEGNPVASLG HSEAETPVDA YSNGQAALMG EKERKKETDD GGRYWKFIDW FCGFKSKSLS KRSLRDLMEE EAVCLQMLEE TRQVKVILNI GLFAVCSLGI FMFVYFSL
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