DNA-directed RNA polymerases I, II, and III subunit…

About DNA-directed RNA polymerases I, II, and III subunit RPABC4

DNA-directed RNA polymerases I, II, and III subunit RPABC4 (POLR2K) is a protein from Homo sapiens identified by UniProt accession P53803, 58 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.

Target properties

Protein name	DNA-directed RNA polymerases I, II, and III subunit RPABC4
UniProt accession	P53803
Gene	POLR2K
Organism	Homo sapiens
Length	58 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (28)

Diseases linked to this target (Open Targets).

HIV infection · score 0.60
acrocephalosyndactyly · score 0.37
influenza · score 0.37
Kartagener Syndrome · score 0.33
primary ciliary dyskinesia · score 0.33
endometrial cancer · score 0.29
neutrophil percentage of leukocytes · score 0.11
lymphocyte percentage of leukocytes · score 0.07
basophil count · score 0.05
basal cell carcinoma · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P53803-F1	alphafold	PREDICTED	85.72	—

Amino-acid sequence (58 residues)

MDTQKDVQPP KQQPMIYICG ECHTENEIKS RDPIRCRECG YRIMYKKRTK RLVVFDAR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

DNA-directed RNA polymerases I, II, and III subunit RPABC4 (POLR2K)