About Phospholipase A and acyltransferase 3
Phospholipase A and acyltransferase 3 (PLAAT3) is a protein
from Homo sapiens identified by UniProt accession
P53816, 162 residues long.
MolForge cross-references it against 0 known binders and
138 disease associations.
Target properties
| Protein name | Phospholipase A and acyltransferase 3 |
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| UniProt accession | P53816 |
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| Gene | PLAAT3 |
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| Organism | Homo sapiens |
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| Length | 162 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (138)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.09
- breast cancer · score 0.07
- LIPE-related familial partial lipodystrophy · score 0.05
- hemoglobin D disease · score 0.05
- CIDEC-related familial partial lipodystrophy · score 0.05
- MODY · score 0.05
- dominant beta-thalassemia · score 0.05
- PPARG-related familial partial lipodystrophy · score 0.05
- PLIN1-related familial partial lipodystrophy · score 0.05
- Familial partial lipodystrophy, Köbberling type · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P53816-F1 | alphafold | PREDICTED | 75.50 | — |
Amino-acid sequence (162 residues)
MRAPIPEPKP GDLIEIFRPF YRHWAIYVGD GYVVHLAPPS EVAGAGAASV MSALTDKAIV KKELLYDVAG SDKYQVNNKH DDKYSPLPCS KIIQRAEELV GQEVLYKLTS ENCEHFVNEL RYGVARSDQV RDVIIAASVA GMGLAAMSLI GVMFSRNKRQ KQ
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