About Monocarboxylate transporter 1
Monocarboxylate transporter 1 (SLC16A1) is a protein
from Homo sapiens identified by UniProt accession
P53985, 500 residues long.
MolForge cross-references it against 0 known binders and
275 disease associations.
Target properties
| Protein name | Monocarboxylate transporter 1 |
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| UniProt accession | P53985 |
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| Gene | SLC16A1 |
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| Organism | Homo sapiens |
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| Length | 500 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (275)
Diseases linked to this target (Open Targets).
- exercise-induced hyperinsulinism · score 0.74
- metabolic myopathy due to lactate transporter defect · score 0.71
- ketoacidosis due to monocarboxylate transporter-1 deficiency · score 0.71
- neurodegenerative disease · score 0.51
- diastolic blood pressure · score 0.43
- systolic blood pressure · score 0.39
- inborn errors of metabolism · score 0.37
- refractive error · score 0.33
- refractive error measurement · score 0.31
- macula measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P53985-F1 | alphafold | PREDICTED | 83.06 | — |
Amino-acid sequence (500 residues)
MPPAVGGPVG YTPPDGGWGW AVVIGAFISI GFSYAFPKSI TVFFKEIEGI FHATTSEVSW ISSIMLAVMY GGGPISSILV NKYGSRIVMI VGGCLSGCGL IAASFCNTVQ QLYVCIGVIG GLGLAFNLNP ALTMIGKYFY KRRPLANGLA MAGSPVFLCT LAPLNQVFFG IFGWRGSFLI LGGLLLNCCV AGALMRPIGP KPTKAGKDKS KASLEKAGKS GVKKDLHDAN TDLIGRHPKQ EKRSVFQTIN QFLDLTLFTH RGFLLYLSGN VIMFFGLFAP LVFLSSYGKS QHYSSEKSAF LLSILAFVDM VARPSMGLVA NTKPIRPRIQ YFFAASVVAN GVCHMLAPLS TTYVGFCVYA GFFGFAFGWL SSVLFETLMD LVGPQRFSSA VGLVTIVECC PVLLGPPLLG RLNDMYGDYK YTYWACGVVL IISGIYLFIG MGINYRLLAK EQKANEQKKE SKEEETSIDV AGKPNEVTKA AESPDQKDTD GGPKEEESPV
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